irritation, impediment, annoyance, thorn, bugbear, headache, stumbling block, nuisance, flashpoint, hindrance, distraction, obstacle, spats, friction, sodium lauryl sulphate, ally, embarrassment, peeve, gripe, eyesore, pollutant, drawback, whipping boy, belligerant, bugaboo, ointment, oxidizing agent, seborrheic keratosis, problem, antagonist, sideshow, concern, bane, detractor, afterthought, occupational hazard, carminative, inconvenience, contretemps, complication, lightning rod, tiff, byproduct, pariah, pet peeve, issue, germicides, earache, ingredient, culprit, contaminant, antagonism, verrucas, seborrhea, snarl, testy, preoccupation, rhinitis, antipathy, punching bag, boon, smogs, enigma, aphrodisiac, scratchiness, frosty, blemish, troublemaker, aggravation, sidelight, adversary, bogeyman, adjunct, malodor, itch, neutralizer, interlocutor, element, softener, oddity, attractant, squabble, eradicator, manifestation, cause celebre, discomfort, blights, irk, interloper, adulterant, unpleasantness, irritancy, hiccup, odor, emollient, symptom, dislike, solanine, nemesis, embarassment, otitis, preservative, irritants, irritations, hazard, constraint, danger, stressor, handicap, impediments, trouble, disincentive, disturbance, excitants, inducement, obstacles, difficulty, excitant, irritating, allergenic, corrosive, astringent, noxious, deleterious, fungicidal, oxidising, oxidizing, antiseptic, antitoxic, hepatotoxic, hygroscopic, toxic, arsenical, insecticidal, poisonous, germicidal, inflammable

acute gastritis, bear's foot, helleborus foetidus, herb of grace, rue, ruta graveolens, setterwort, sneeze, stinking hellebore

bother, botheration, pain, pain in the ass, pain in the neck