devastate, decimate, paralyze, undermine, imperil, hamper, threaten, disrupt, destroy, hinder, stymie, debilitate, hobble, ruin, derail, weaken, endanger, undercut, jeopardize, crimp, eviscerate, impede, stifle, depress, affect, destabilize, thwart, scuttle, deprive, curtail, detrimental, complicate, overwhelm, impair, emasculate, scupper, sabotaging, constrain, backfire, erode, obliterate, starve, hurt, impoverish, inhibit, deplete, ravage, marginalize, defang, damaging, demoralize, upend, exacerbate, tarnish, constrict, hamstringing, overtax, enfeeble, harm, dent, kill, unhinge, strangle, aggravate, displace, embolden, dampen, galvanize, saps, annihilate, embarrass, choke, frustrate, prolong, europeanize, forestall, incapacitate, blow, diminish, wipe, stave off, undo, denude, injure, revive, reshape, roil, unsettle, shortchange, frighten, avert, spur, dooming, embitter, inflict, deathblow, discourage, topple, squelch, decapitate, bankrupted, restrict, cripples, invalid, invalids, wreck, lunatic, leper, imbecile, bondage, coward, idiots, impotency, outcast, derelict, derelicts, hunchback, imbeciles, misfit, misfits, outcasts, pauper, castle, abbey, battlemented, beaten, carat, castellated, chancel, citadel, city, cobwebby, convent, coyote, daft, decrepit, demolished, diaphanous, dilapidated, dismantled, eaftern, ectoplasmic

crookback, hamstring, humpback

hamstring, restriction endonuclease, restriction enzyme, restriction nuclease

maim, unfortunate, unfortunate person

lame