devastate, decimate, paralyze, undermine, imperil, hamper, threaten, disrupt, destroy, hinder, stymie, debilitate, hobble, ruin, derail, weaken, endanger, undercut, jeopardize, crimp, eviscerate, impede, stifle, depress, affect, destabilize, thwart, scuttle, deprive, curtail, detrimental, complicate, overwhelm, impair, emasculate, scupper, sabotaging, constrain, backfire, erode, obliterate, starve, hurt, impoverish, inhibit, deplete, ravage, marginalize, defang, damaging, demoralize, upend, exacerbate, tarnish, constrict, hamstringing, overtax, enfeeble, harm, dent, kill, unhinge, strangle, aggravate, displace, embolden, dampen, galvanize, saps, annihilate, embarrass, choke, frustrate, prolong, europeanize, forestall, incapacitate, blow, diminish, wipe, stave off, undo, denude, injure, revive, reshape, roil, unsettle, shortchange, frighten, avert, spur, dooming, embitter, inflict, deathblow, discourage, topple, squelch, decapitate, bankrupted, restrict, cripples, invalid, invalids, wreck, lunatic, leper, imbecile, bondage, coward, idiots, impotency, outcast, derelict, derelicts, hunchback, imbeciles, misfit, misfits, outcasts, pauper, castle, abbey, battlemented, beaten, carat, castellated, chancel, citadel, city, cobwebby, convent, coyote, daft, decrepit, demolished, diaphanous, dilapidated, dismantled, eaftern, ectoplasmic

crookback, hamstring, humpback, hunchback

hamstring, restriction endonuclease, restriction enzyme, restriction nuclease

maim, unfortunate, unfortunate person, weaken

lame