Definitions of operate:

• verb:   direct or control; projects, businesses, etc.
• verb:   happen
• verb:   handle and cause to function

  Example: "Do not operate machinery after imbibing alcohol"

• verb:   perform surgery on

  Example: "The doctors operated ont he patient but failed to save his life"

• verb:   perform as expected when applied
• verb:   perform a movement in military or naval tactics in order to secure an advantage in attack or defense
• verb:   keep engaged