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Definitions of colocynth:
  • noun:   A viny plant, Citrullus colocynthis, native to the Mediterranean Basin and Asia. It produces a lemon-sized, yellowish, green-mottled, spongy, and extremely bitter fruit.
  • noun:   The powdered pulp of this fruit, a powerful hepatic stimulant and hydragogue cathartic used as a strong laxative.

(Definitions from Wiktionary)

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